A release said that Covaxin has been demonstrated in clinical trials to generate a broader immune response "against the whole virus covering important antigens such as S-protein, RBD, and N-protein whereas currently approved vaccines in the US target only S-protein antigen"
A syndrome known as immunological "exhaustion" occurs when the immune system, particularly T cells, are severely weakened by cancer and severe viral infections. Overcoming immunological exhaustion is a key goal in the development of new drugs for serious viral infections or cancer.
The human immune system is a very intricate network of cells, signals, and reactions that is strictly regulated in order to ensure that the body can fight off infection without injuring its own tissues
According to new research, mice with colorectal cancer who have tumours with high levels of ammonia have fewer T cells and are less responsive to immunotherapy. Ammonia, which is crucial for anti-tumor immunity, has been demonstrated to impede the proliferation and operation of T cells.
The immune system, including T cells, is known to be compromised by severe viral infections and cancer, a condition known as immunological 'exhaustion'. The development of novel medicines for cancer or severe viral infections has a major focus on overcoming immunological fatigue.
The regulation of inflammation has been better understood thanks to research from Trinity College Dublin scientists. Recent research has revealed that a crucial immunological alarm protein that was previously thought to slow down the immune response really has the opposite effect.
Nearly three years into the pandemic, many of us now carry antibodies against the virus--due to an infection or two, a few doses of mRNA vaccine, or a round of monoclonal-antibody treatment. But not all immune responses are created equal, and how we first developed our antibodies may influen
Scientists at Duke-NUS Medical School and colleagues in Singapore have sequenced the response to viral infection in colony-bred cave nectar bats (Eonycteris spelaea) at single-cell resolution. Published in the journal Immunity, the findings contribute to insights into bat immunity that could
A Ludwig Cancer Research study has revealed a single protein expressed at high levels by cancer cells across a broad range of malignancies that erects a multifaceted barrier to anti-cancer immune responses in mouse models of cancer and so shields tumours from immune detection and destruction
Researchers at Duke Health have reported that an immune response that likely evolved to help fight infections appears to be the mechanism that drives human immunodeficiency virus (HIV) into a latent state, lurking in cells only to erupt anew.
Though the COVID-19 pandemic provided a brief respite, influenza virus is back in circulation and, as usual, poses a special danger to people over the age of 65. But why are older people more susceptible to the flu? New research from the U-M Medical School, published in Nature Communications