Salmonella infections kill about a million people worldwide each year, and better vaccines for both typhoid fever and non-typhoidal Salmonella disease are needed badly. Memory T cells, which are critical for a vaccine that induces a powerful immune response, can be recruited into the liver o
The dendritic cells are the ones responsible for processing foreign proteins, molecules or particles, and presenting them to the immune system T-cells, acting as messengers and initiating the immune response.
Senescent cells, or cells that stop reproducing but do not die, can collect in the body over time and fuel chronic inflammation, which leads to illnesses including cancer and degenerative disorders.
Many vaccines contain compounds known as adjuvants in addition to an antigen that stimulates the immune system. A Chinese research team has now created two novel broad-spectrum adjuvants that can dramatically boost the immune response to vaccines using computer-aided molecular design and ma
Isolated from other cells in a laboratory dish, tumour cells won't reveal their actual nature. Rice University researchers created an improved tumour model that houses osteosarcoma cells alongside immune cells known as macrophages inside a three-dimensional framework designed to simulate bon
C-reactive protein (CRP) biological function has long been unknown. Researchers at Linkoping University in Sweden have discovered that this protein is beneficial in the inflammatory disease systemic lupus erythematosus or SLE. According to the study published in the Journal of Autoimmunity,
PCB2DG, an anti-inflammatory polyphenol, inhibits glutamine absorption by targeting and directly interacting with the main glutamine transporter protein, alanine serine cysteine transporter 2 (ASCT2). This reduction in intracellular glutamine accumulation in CD4+ T cells also inhibits the pr
Tumor cells typically alter their energy metabolism and increase glucose uptake to support their rapid division and spread. This limits glucose availability for immune cells and therefore dampens the body's anti-cancer immune response.
A new study led by Bruno Silva Santos, group leader and vice-director at the Instituto de Medicina Molecular Joo Lobo Antunes (iMM; Portugal), and published in the scientific journal Cell Reports discovered that T cells influence the transfer of maternal microbiota during birth and nursing,
A newly published paper in The Lancet shows that an experimental vaccine against Marburg virus (MARV) was safe and induced an immune response in a small, first-in-human clinical trial. The vaccine, developed by researchers at the National Institute of Allergy and Infectious Diseases (NIAID),
An approved medication for the treatment of psoriasis is now starting a significant clinical investigation. Patients who have just received a type 1 diabetes diagnosis will test the medication. According to the theory, the medication might maintain the patient's remaining capacity to produce
"It's easy to deliver and doesn't need any syringe or needle and most important it produces three immune responses, IgG, IgA, & T cell response. No other vaccine in the world can produce three responses," said Dr Krishna Ella, Chairman & MD, Bharat Biotech on the launch of the 'iNCOV