She won the last of her seven Wimbledon singles titles in 2016 but reached the final in 2018 and 2019 after returning to the court after having a baby.
Swiatek, the freshly crowned French Open champion, will look to extend her 35-match winning streak when she takes on qualifier Jana Fett after Friday's draw at the All England Club.
The defending champion is the top seed after the Russian world number one Daniil Medvedev got banned from taking part while German world number two Alexander Zverev is out due to injury.