In her Centre Court debut, Anisimova dropped the first set from a winning position, but she bounced back in two hours, 7 minutes for a 6-7(4), 6-2, 6-1 win.
Nine days after knocking the Czech out of the Eastbourne International in the second round, Boulter repeated the feat on Centre Court at Wimbledon, with a 3-6, 7-6(4), 6-4 win over the 2021 finalist.
Murray featured in the late match but was met by the ruthless power of John Isner, who served his way to a 6-4 7-6 6-7 6-4 victory in over three hours.