T cells, a key element of the immune system, are crucial in preventing viral infections. Extracellular vesicles are shown to be crucial in the activation of these cells in a mouse model by a team led by Prof. Thomas Brocker and Jan Kranich from the LMU Biomedical Center.
Senescent cells, or cells that stop reproducing but do not die, can collect in the body over time and fuel chronic inflammation, which leads to illnesses including cancer and degenerative disorders.
Despite the fact that chimeric antigen receptor T-cell (CAR-T) therapy has transformed cancer treatment, few studies have looked into its impact on long-term patient quality of life - an aspect of care that is frequently compromised when patients receive traditional intensive cancer medicati
CAR T-cell treatments, which are specifically designed to target cancer cells, has heralded a new era in the treatment of human cancers, particularly hematologic malignancies. But all too frequently, they exhibit a disconcerting characteristic derived from the immune system's own cells: a sh
Researchers at the Perelman School of Medicine at the University of Pennsylvania have been working on a preclinical study that focuses on a novel strategy that uses a "one-two punch" to assist T cells in attacking solid tumours. The results, which were reported in the Proceedings of the Nati
Researchers from Weill Cornell Medicine, Johns Hopkins University School of Medicine, and Columbia University Irving Medical Center have shown that pregnant women with anxiety have an immune system that differs biologically from pregnant women without anxiety.
Experiments on mice and human cells reveal that the number of specialised immune cells ready to combat skin cancer increased when a novel therapy prevented their egress from melanoma tumours.
PCB2DG, an anti-inflammatory polyphenol, inhibits glutamine absorption by targeting and directly interacting with the main glutamine transporter protein, alanine serine cysteine transporter 2 (ASCT2). This reduction in intracellular glutamine accumulation in CD4+ T cells also inhibits the pr
A new study led by Bruno Silva Santos, group leader and vice-director at the Instituto de Medicina Molecular Joo Lobo Antunes (iMM; Portugal), and published in the scientific journal Cell Reports discovered that T cells influence the transfer of maternal microbiota during birth and nursing,
CAR T-cell therapy, a sort of cancer treatment in which the immune system's T cells are trained to attack tumour cells, was found to be effective in mice with ovarian cancer, according to a study.
According to a study, CAR T-cell therapy, a type of cancer treatment in which the immune system's T cells are trained to attack tumour cells, is successful in mice with ovarian cancer.