The Spitfire is widely seen as the most famous British fighter aircraft in history.
It played a key role in the Battle of Britain fought between the RAF and the German Luftwaffe in the summer of 1940.
There were 15 people, including eight crew members and seven passengers, on board when the military cargo plane crashed. Who the passengers were and where they were headed was not clear.
A small plane crash took place on Florida highway on Friday afternoon, leaving two people dead, Fox News reported, citing the Collier County Sheriff's Office, which confirmed it to the publication.
The move follows last week's plane crash in Russia's Belgorod region, near the Ukrainian border, with Moscow accusing Kyiv of downing a military transport carrying Ukrainian prisoners of war destined for exchange.
"There were 65 Ukrainian prisoners of war who were being moved to the Belgorod Region for an exchange, and three escorts on board," Russia's Defence Ministry said as cited by TASS.
An unspecified number of people died after a plane crashed in Canada's Northwest Territories near the town of Fort Smith while it was headed to a diamond mine, CNN reported, citing officials.
Confirming the plane crash in Afghanistan's Badakhshan province in the early morning hours on Sunday, the Ministry of Civil Aviation said the aircraft was an air ambulance flying from Thailand to Moscow.