These will be the last fixtures for all three teams before they travel to Australia for the ICC Men's T20 World Cup in Australia, to be held from October 16.
Karthik had smashed 55 runs off 27 balls in the fourth T20I against South Africa in Rajkot. His knock helped Team India reach a defendable score of 169.
With the T20I series tied at 2-2 the fifth and final match between India and South Africa here at M Chinnaswamy Stadium, Bengaluru becomes a virtual final.