Hypertension may impair the brain far earlier than previously understood -- even before a measurable rise in blood pressure occurs -- according to a new preclinical study from Weill Cornell Medicine. The changes help explain why hypertension is a major risk factor for developing cognitive di
A recent study marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells.
This facility ushers in a new era of gene and cell therapies to tackle scientific challenges such as targeted gene expression, immune system modulation, and long-term cell survival. The work will span from boosting immune responses against cancer to ensuring that therapeutic proteins are saf
Short-lived proteins control gene expression in cells to carry out a variety of crucial functions, from aiding in the formation of neural connections to supporting the body's immune system. These proteins are created in the nucleus and, after performing their function, are promptly eliminate
A recent study discovered that gene expression within the apicoplast, an organelle in the malaria parasite Plasmodium falciparum, is regulated by melatonin (the circadian signalling hormone) in host blood and intrinsic parasite cues via a factor called ApSigma. The regulatory system highligh
T cells encounter various mechanical cues in various tissues. In order to demonstrate that more elastic tissues encourage T cells to develop into effector-like T cells with potent tumor-killing potential, while more viscous tissues encourage them to develop into memory-like T cells, research
There is growing evidence that illnesses are more likely to affect astronauts in space. For instance, respiratory and non-respiratory illnesses are rather prevalent among astronauts on board the International Space Station (ISS), as well as skin rashes. Additionally, it is known that astrona
New research sheds light on how an enzyme that aids in the regulation of ageing and other metabolic processes accesses our genetic material to modify gene expression within the cell.
In the pancreas, various types of beta cells produce insulin, which aids in blood sugar regulation. According to Weill Cornell Medicine researchers, losing a particularly productive type of beta cell may contribute to the development of diabetes.
Two to three metres of DNA can fit inside a single cell, thus it can only be stored by being wound tightly into coils. The answer is chromatin, a compound of DNA encased in histone-like proteins. This complex gradually folds into the multi-layered arrangement of loops, domains, and compartme
Rice University scientists have enlisted widely used cancer therapy systems to control gene expression in mammalian cells, a feat of synthetic biology that could change how diseases are treated.
The human body runs on a finely tuned clock synchronized to the 24-hour cycle of Earth's rotation, known as the circadian clock, which controls various physiological processes such as the sleep-wake cycle, hormone production, and metabolism.