Study reveals aerobic exercise could have final say on fatty livers

Updated:5 years, 2 months ago

New Delhi, Aug 03 (ANI): A new study highlights that fitness may be a more important clinical endpoint for improvement in patients with fatty liver diseases during exercise trials, rather than weight loss. If left untreated, MAFLD can lead to serious complications like liver fibrosis (scarring), cirrhosis, liver failure and liver cancer, as well as cardiovascular and metabolic issues. Risk factors for developing MAFLD include type 2 diabetes and obesity. The global estimated prevalence of MAFLD is 25 per cent, making it the leading cause of chronic liver disease worldwide, and is quickly becoming the leading cause of cirrhosis and liver cancer in liver transplant candidates in the western world. Up to now, due to the lack of approved pharmacological interventions, treatment has been a combination of prescribed weight loss and physical activity, with a weight loss target of 7-10 per cent being the primary treatment endpoint. There is some evidence that exercise training alone without significant weight loss can reduce liver fat content (assessed using non-invasive methodologies such as transient elastography and ultrasound) in MAFLD patients. However, the independent effects of exercise alone on biopsy-measured outcomes (the gold standard for diagnosing and assessing MAFLD) have been unknown. The study further stressed that increased fitness, the result of aerobic exercise participation, maybe a more important clinical endpoint for improvement in MAFLD patients during exercise trials, rather than weight loss.

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Study reveals aerobic exercise could have final say on fatty livers

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