Not genetics, lifestyle leads to most premature heart diseases

Updated:6 years, 1 month ago

New Delhi, Sep 05 (ANI): Physical inactivity, smoking, high blood pressure, diabetes, and high cholesterol play a greater role than genetics in many young patients with heart diseases, suggests a new study. The research presented at 'ESC Congress 2019' showed that healthy behaviours should be a top priority for reducing heart disease even in those with a family history of early-onset. The study enrolled 1,075 patients under 50, of whom 555 had coronary artery disease (known as premature CAD). Specific conditions included stable angina, heart attack, and unstable angina. Five modifiable risk factors were assessed: physical inactivity, smoking, high blood pressure, diabetes, and high cholesterol. Nearly three-quarters (73 per cent) of patients had at least three of these risk factors compared to 31 per cent of controls. In both groups, the likelihood of developing CAD increased exponentially with each additional risk factor. The probability of CAD was 3, 7, and 24 times higher with 1, 2, and 3 or more risk factors, respectively. All participants underwent genome sequencing. These data were used to develop a genetic risk score containing 33 variants thought to contribute to CAD or risk factors such as high blood pressure. The average score was higher in patients than controls. The score was also an independent predictor for premature CAD. However, the contribution of genetics to risk of CAD declined as the number of modifiable factors rose.

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Not genetics, lifestyle leads to most premature heart diseases

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