ADD ANI AS A TRUSTED SOURCE
googleads
Menu

Video

Here's what controls the tips of our chromosomes

Here's what controls the tips of our chromosomes

New Delhi, Mar 1 (ANI): In a new, a research team from Instituto Gulbenkian de Ciencia (IGC; Portugal), led by Jose Escandell and Miguel Godinho Ferreira, discovered a key aspect of the regulation of telomeres - structures that appear at the tips of our chromosomes.They work as a protective cap that prevents genetic material from unfolding and corroding away. However, when they do not work properly, telomeres can lead to the total erosion of genetic material and can trigger cancer and age-related diseases.There is an increasing number of human syndromes attributed to telomeres malfunction. One such disease was recently identified as the result of a malfunction of a protein complex known as CST, which is responsible for maintaining telomeres.Deficiencies in this complex give rise to a telomeropathy known as Coats Plus. This syndrome is genetically inherited and characterised by abnormalities of the gastrointestinal system, bones, brain and other parts of the body.The work of the IGC researchers now unveils the regulation of the "S" component of that CST complex.The researchers discovered that STN1 (the protein that corresponds to the S component) is regulated by a chemical modification that results in the insertion of phosphorus in this protein, and it can be reversed by an enzyme, the phosphatase SSU72. In this way, it allows telomere duplication and telomerase regulation, which is the enzyme that elongates telomeres.The researchers also showed that this process is identical both in yeast and in human cells. This means that the regulation of the 'S' component has been conserved throughout evolution of species, which somehow reveals the importance of this process for the correct functioning of cells.This opens new avenues to the discovery of therapies capable of dealing with debilitating diseases associated to defects in telomeres. "The unanticipated role of this evolutionary conserved phosphatase is reminiscent of the regulation of the cell cycle by phosphatases that counteract the role of kinases, thus re-establishing the ground state of 'once and only once' cell cycle processes", said investigator Miguel Godinho Ferreira."With this work, we now understand better how telomere regulation works, a key process in cancer and ageing", says Jose Escandell, first author of the publication," Ferreira added. Telomeres structures that appear at the tips of our chromosomes work as a protective cap

More Videos

India reports 10,158 new cases, 5,356 recoveries in last 24 hours
1:12

India reports 10,158 new cases, 5,356 recoveries in last 24 hours

High exposure to glyphosate in pregnancy can cause lower birth weights in babies: Study

High exposure to glyphosate in pregnancy can cause lower birth weights in babies: Study

Study identifies mechanism otherwise found in metastasizing cancer cells
01:19

Study identifies mechanism otherwise found in metastasizing cancer cells

Study highlights what connects human senses and thoughts
01:11

Study highlights what connects human senses and thoughts

National Videos

Northeast India’s growth highlighted at UN
02:01

Northeast India’s growth highlighted at UN

Ahmedabad Junction’s ₹20 AC Waiting Hall Sees Massive Response

Ahmedabad Junction’s ₹20 AC Waiting Hall Sees Massive Response

Hamirpur Celebrates Rebirth of Chandrawal River

Hamirpur Celebrates Rebirth of Chandrawal River

Rajasthan CM Bhajanlal Sharma attends CII Rajasthan session on $4.3 trillion economy vision

Rajasthan CM Bhajanlal Sharma attends CII Rajasthan session on $4.3 trillion economy vision

एलपीजी की जमाखोरी व कालाबाजारी पर होगी सख्त कार्रवाईः मुख्यमंत्री भजनलाल शर्मा

एलपीजी की जमाखोरी व कालाबाजारी पर होगी सख्त कार्रवाईः मुख्यमंत्री भजनलाल शर्मा

हमीरपुर में चंद्रावल  नदी का पुनर्जन्म

हमीरपुर में चंद्रावल नदी का पुनर्जन्म

Gujarat’s Dairy Hero: Deepak Patel and the Science of Better Breeding

Gujarat’s Dairy Hero: Deepak Patel and the Science of Better Breeding

Rajasthan CM Bhajanlal Sharma holds ‘crucial’ meeting on LPG & Petroleum supply at CMR

Rajasthan CM Bhajanlal Sharma holds ‘crucial’ meeting on LPG & Petroleum supply at CMR

World Videos

Security deployment, curfew expose governance crisis in PoGB

Security deployment, curfew expose governance crisis in PoGB

Watch! Latest visuals emerge as Middle-East situation worsen amid escalating Iran-Israel war
04:08

Watch! Latest visuals emerge as Middle-East situation worsen amid escalating Iran-Israel war

Kyoto hosts cooking test to certify foreign Japanese cuisine chefs
02:35

Kyoto hosts cooking test to certify foreign Japanese cuisine chefs

People of Nepal, leaders vote to elect new government after Gen-Z ptotest | Nepal General Elections
03:51

People of Nepal, leaders vote to elect new government after Gen-Z ptotest | Nepal General Elections

Nepal: Thousands of voters leave Kathmandu ahead of Polls
02:27

Nepal: Thousands of voters leave Kathmandu ahead of Polls

PoJK: Health workers protest in Muzaffarabad over ending allowance demands
03:29

PoJK: Health workers protest in Muzaffarabad over ending allowance demands

UN Rights chief praises India’s civil society
00:50

UN Rights chief praises India’s civil society

Nepali Interim PM urges voters to participate ahead of Thursday’s silence period
01:41

Nepali Interim PM urges voters to participate ahead of Thursday’s silence period

Entertainment Videos

‘Subedaar’ actor Aditya Rawal calls father Paresh Rawal a versatility icon
08:49

‘Subedaar’ actor Aditya Rawal calls father Paresh Rawal a versatility icon

Siddhant Chaturvedi & Mrunal Thakur shares their manifesting role on 'Do Deewane Seher Mein'
09:11

Siddhant Chaturvedi & Mrunal Thakur shares their manifesting role on 'Do Deewane Seher Mein'

BREAKING: 4 round fired outside Director Rohit Shetty’s residence, police start probe
03:39

BREAKING: 4 round fired outside Director Rohit Shetty’s residence, police start probe

‘Kohrra 2’ cast Mona Singh, Rannvijay Singha, Barun Sobti on how OTT transformed storytelling
15:18

‘Kohrra 2’ cast Mona Singh, Rannvijay Singha, Barun Sobti on how OTT transformed storytelling

‘Gadar 2 fueled Border 2…’ Producer Bhushan Kumar, Director Anurag Singh on cast, future, more

‘Gadar 2 fueled Border 2…’ Producer Bhushan Kumar, Director Anurag Singh on cast, future, more

Top film critic, trade analyst exposes dynamics of fake PR, predicts future of Hindi films in 2026

Top film critic, trade analyst exposes dynamics of fake PR, predicts future of Hindi films in 2026

Watch: Rani Mukherjee gets emotional recalling Karan Johar’s heartwarming gesture
05:43

Watch: Rani Mukherjee gets emotional recalling Karan Johar’s heartwarming gesture

Actor Sunil Shetty shares mixed emotions ahead of son Ahan Shetty’s ‘Border 2’ release
03:32

Actor Sunil Shetty shares mixed emotions ahead of son Ahan Shetty’s ‘Border 2’ release

Business Videos

Sensex-Nifty open red, skids over 2,500 points amid Iran crisis; what it means for retail investors?
04:46

Sensex-Nifty open red, skids over 2,500 points amid Iran crisis; what it means for retail investors?

SEBI Chief Tuhin Kanta Pandey speaks on ‘Jane Street’ crackdown and enhanced surveillance measures
03:56

SEBI Chief Tuhin Kanta Pandey speaks on ‘Jane Street’ crackdown and enhanced surveillance measures

Impact of Middle East crisis! Will retail investors feel safe investing in IPOs? SEBI Chief Explains
02:43

Impact of Middle East crisis! Will retail investors feel safe investing in IPOs? SEBI Chief Explains

Gautam Adani visits Baba Baidyanath temple in Deoghar, performs darshan and offers prayers
05:31

Gautam Adani visits Baba Baidyanath temple in Deoghar, performs darshan and offers prayers

“Increase export…” Auto Industry expert Bagga outlines industry roadmap after trade deal with US
04:12

“Increase export…” Auto Industry expert Bagga outlines industry roadmap after trade deal with US

Distilleries Association seeks GST cuts on flex-fuel vehicles to boost in domestic demand
12:23

Distilleries Association seeks GST cuts on flex-fuel vehicles to boost in domestic demand

‘75 years old relation, beautiful Country…’ Sibi George hails India‑Iran Bilateral Ties
06:56

‘75 years old relation, beautiful Country…’ Sibi George hails India‑Iran Bilateral Ties

Monetary Policy Committee keeps the repo rate unchanged at 5.25%: RBI Governor Sanjay Malhotra
25:44

Monetary Policy Committee keeps the repo rate unchanged at 5.25%: RBI Governor Sanjay Malhotra

Sports Videos

T20 World Cup IND vs PAK: Lt Gen KJS Dhillon roasts Pakistan after India’s thundering win
02:52

T20 World Cup IND vs PAK: Lt Gen KJS Dhillon roasts Pakistan after India’s thundering win

Ishan Kishan scores 77 off 40, coach Uttam Mazumdar hails him, saying India’s morale soars
01:41

Ishan Kishan scores 77 off 40, coach Uttam Mazumdar hails him, saying India’s morale soars

Indian fans erupt nationwide as Team India defeats Pakistan in ICC T20 World Cup 2026 clash
06:38

Indian fans erupt nationwide as Team India defeats Pakistan in ICC T20 World Cup 2026 clash

Ishan Kishan’s parents ‘beam with pride’ after son’s powerful knock against Paksitan in T20I WC 2026
02:10

Ishan Kishan’s parents ‘beam with pride’ after son’s powerful knock against Paksitan in T20I WC 2026

ICC T20 World Cup! This is how Pakistan takes full U-turn to play match with India, BCCI VP explains
03:13

ICC T20 World Cup! This is how Pakistan takes full U-turn to play match with India, BCCI VP explains

WATCH: Gautam Gambhir hosts a ‘special’ dinner for members of the Indian T20 cricket team
03:19

WATCH: Gautam Gambhir hosts a ‘special’ dinner for members of the Indian T20 cricket team

India beats USA by 29 runs in ICC T20 World Cup 2026 opener
05:03

India beats USA by 29 runs in ICC T20 World Cup 2026 opener

Fans cheer as Team India crushes New Zealand, winning T20I series 4-1 with a massive victory
03:41

Fans cheer as Team India crushes New Zealand, winning T20I series 4-1 with a massive victory

Home About Us Our Products Advertise Contact Us Terms & Condition Privacy Policy

Copyright © aninews.in | All Rights Reserved.