The top seed was in command from the beginning of the match which lasted for two hours and 11 minutes. Medvedev started the match with a service break establishing his authority over the French player.
Williams, who is now 40 and holds the current ranking of No. 605, upset Estonia's Anett Kontaveit, the No. 2 seed, in a see-saw encounter, to advance to the third round of the US Open. This win keeps her pursuit of Margaret Court and the record 24 major victories alive.