Chasing 296, England was not off the finest start, opener Alex Lees was run out for just 9 at the team's score of 17. Zak Crawley and Ollie Pope resumed the chase for England.
He will retire having played a total of 248 ODIs, scoring 7,701 runs with 14 centuries, as well as 115 T20Is, adding a further 2,458 runs and 14 fifties
Kyle Mayers batted sensibly when required and attacked the bad deliveries when they came to score his second Test century and put his side in control at stumps on day two.
The Blue Tigresses created a flurry of chances and took the lead in the 8th minute, but the opponents picked up the win in the end, drawing level in the first half, before scoring three more on the other side of the lemon break.
A cross from Neha landed at the feet of Kajol who tucked the ball away neatly into the back of the net from a header. But in return Chile U17 scored three goals.