Zverev overcame the former World No. 3 with 6-7(2), 7-6(8), 6-1, and 6-1. The German, who has advanced to the Round of 16 in each of his last four tournament appearances, will face sixth-seeded Jannik Sinner, who earlier in the day defeated 2016 US Open winner Stan Wawrinka in four sets.
The world number two men's doubles pair defeated the world number 10 pair of Leo Rolly Carnando & Daniel Marthin of Indonesia in their round of 16 match.
Nishna Patel, who shot rounds of 78-74 tied for 33rd place alongside her teammate Mannat Brar (81-71). The top 64 players moved into the match play segment, where Nishna won her first match in the Round of 32 against Charlotte Noughton on the second extra hole.
The Commonwealth gold medallist got better of his fellow national player Priyanshu Rajawat in a competitive three-game affair. Sen emerged victorious as he went on to win a thrilling contest by 21-15, 12-21, 24-22 scoreline.