The encounter between both last year's quarterfinalists was a highly anticipated one but it was Pegula who prevailed over the 2021 Roland Garros champion after a match that lasted one hour and 41 minutes
This was the Pole's second major title of 2022, having won the Roland Garros earlier in June this year. The two-time French Open winner continued her dominant run this year and brought the Tunisian player's second straight chance of winning the US Open to a halt.
The 18-year-old American, who reached her first Grand Slam final at the Roland Garros earlier this month, registered a 7-5, 6-4 win over fourth seed Pliskova in just one hour and 37 minutes.
Rafael Nadal has climbed to No. 4 spot in the ATP Rankings after he captured a historic 14th French Open title and record-extending 22nd Grand Slam trophy in Paris last week.
2016 champions Caroline Garcia and Kristina Mladenovic came back from a set down for the third time to win their home major, overcoming Coco Gauff and Jessica Pegula in the Roland Garros women's doubles final.
French Open women's champion Iga Swiatek said she was "overwhelmed" when she saw that Poland striker Robert Lewandowski was in attendance to witness her claim a second Grand Slam title in Paris.
World Number 1 Iga Swiatek expressed happiness following her second French Open title win after defeating American teenager Coco Gauff in the finals of the Roland Garros 2022.