Playing in Arthur Ashe Stadium, the 24-year-old played fearlessly throughout the three-hour, 31-minute thriller to clinch the match against Nadal 6-4, 4-6, 6-4, 6-3.
Nadal and Gasquet, who had the same month and day of birth in June 1986, reconnected at the USTA Billie Jean King National Tennis Center for what would be their 18th career meeting. Over time, not much has changed in terms of results. With a commanding 6-0, 6-1, 7-5 victory in the third roun
The top seed was in command from the beginning of the match which lasted for two hours and 11 minutes. Medvedev started the match with a service break establishing his authority over the French player.
Williams, who is now 40 and holds the current ranking of No. 605, upset Estonia's Anett Kontaveit, the No. 2 seed, in a see-saw encounter, to advance to the third round of the US Open. This win keeps her pursuit of Margaret Court and the record 24 major victories alive.
Daniel Elahi Galan proved too good for Tsitsipas and clinched the match in four sets 6-0, 6-1,3-6, 7-5. Tsitsipas was in contention to become the world number one before entering the final Grand Slam of the year but this loss has put his hopes of doing so to rest.
Playing in a completely filled stadium and amidst celebrities in the crowd, Serena delivered yet another dominating performance to advance to the next round.
The 35-year-old is striving to grab a seventh Wimbledon crown and 21st major title as he aims to close the gap on 22-time Grand Slam champion Rafael Nadal.