Search For "mouse model"
Facial changes in Down Syndrome have genetic basis, says study
Updated : 2 years, 10 months ago IST
The Francis Crick Institute, King's College London, and University College London researchers shed light on the genetics underpinning changes in the structure and form of the face and skull in a mouse model of Down Syndrome.
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Study suggests to new way to treat chronic transplant rejection
Updated : 2 years, 10 months ago IST
In a mouse model of kidney transplantation, researchers from the University of Pittsburgh discovered a type of immune cell that drives chronic organ transplant failure and discovered pathways that could be therapeutically targeted to enhance patient outcomes. The findings were reported in
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Study reveals how memory T cells induces immunity in people with Salmonell
Updated : 2 years, 11 months ago IST
Salmonella infections kill about a million people worldwide each year, and better vaccines for both typhoid fever and non-typhoidal Salmonella disease are needed badly. Memory T cells, which are critical for a vaccine that induces a powerful immune response, can be recruited into the liver o
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Study reveals how extracellular vesicles boost T cells
Updated : 2 years, 11 months ago IST
T cells, a key element of the immune system, are crucial in preventing viral infections. Extracellular vesicles are shown to be crucial in the activation of these cells in a mouse model by a team led by Prof. Thomas Brocker and Jan Kranich from the LMU Biomedical Center.
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Muscle health depends on lipid synthesis: Research
Updated : 2 years, 11 months ago IST
Researchers at the Institute of Molecular Biotechnology (IMBA) of the Austrian Academy of Sciences characterize how the enzyme PCYT2 affects muscle health in disease and aging in laboratory mouse models. The findings are published on in Nature Metabolism.
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Researchers circumvent radiation resistance in subtypes of brain tumours
Updated : 3 years, 1 month ago IST
Researchers have uncovered a gene that is overexpressed in mutated IDH1. Studies in human cells and a novel mouse model both show that this gene, called ZMYND8, plays a critical role in radiation resistance. When they knocked down the gene, the glioma cells became responsive to radiation tre
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New research identifies potential hepatoblastoma treatment target
Updated : 3 years, 1 month ago IST
The research group used the mouse model to test how inhibiting HSF1 early in tumour development would impact cancer growth.
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Researchers reveal diabetic retinopathy cause blindness in adults
Updated : 3 years, 1 month ago IST
Diabetic retinopathy, which results in progressive damage to the blood vessels in the light-sensitive tissue at the back of the eye, is the main cause of blindness in adults in the United States. However, a study suggested that the small leaky intestine, which reduces the barrier between gut
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Study finds common mechanism tumours use to suppress immune responses
Updated : 3 years, 3 months ago IST
A Ludwig Cancer Research study has revealed a single protein expressed at high levels by cancer cells across a broad range of malignancies that erects a multifaceted barrier to anti-cancer immune responses in mouse models of cancer and so shields tumours from immune detection and destruction
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Researchers pinpoint potential treatment for lethal childhood cancer
Updated : 3 years, 4 months ago IST
Researchers discovered that by blocking the production of an enzyme called DHODH, they were able to halt the growth of MYC gene-amplified medulloblastoma in mouse models, the most aggressive subtype of this cancer.
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Study: Gel-like, radioactive tumour implant obliterates pancreatic cancer
Updated : 3 years, 4 months ago IST
Washington [US], October 22 (ANI): Biomedical engineers have demonstrated the most effective treatment for pancreatic cancer in mouse models ever recorded. While most mouse trials consider simply halting growth a success, the new treatment completely eliminated tumors in 80% of mice across s
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Researchers develop method to detect Alzheimer's disease in blood samples
Updated : 3 years, 5 months ago IST
Sapporo [Japan], October 7 (ANI): Researchers have devised a way to identify amyloid build-up in the brain, a symptom of Alzheimer's disease, using biomarkers found in blood samples.
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