Twelve months ago, the Serbian was knocked out in the third round by the Italian in the Principality, and history threatened to repeat itself in this year's edition as Musetti led by a break early on.
The Italian Sinner outplayed Grigor Dimitrov 6-3, 6-1 to win his first trophy at the hard-court event on the back of one of the best backhand performances of his career
The World No. 4 has set an Australian Open final rematch with Jannik Sinner in Friday's semi-finals, hoping to reach his third final in four appearances.
The Italian with a squeaky-clean performance defeated Czech Tomas Machac 6-4, 6-2, converting four of his 11 break chances in a match that lasted for 91 minutes.
Medvedev and Alcaraz will be meeting in a rematch of the 2023 edition on Monday. Last year, Medvedev suffered a straight-set 6-3, 6-2 loss to the rising Spanish star.