A potentially game-changing treatment for people with, or at risk of, blood clots have been found effective by an international team of researchers led by McMaster University's Jeffrey Weitz.
Lipopolysaccharide, a virulence factor produced by bacteria, is a toxin that can cause systemic inflammation via circulation. In a recently completed study, genetic markers were discovered that are associated with a heightened lipopolysaccharide level in the blood.
Researchers compared milvexian with enoxaparin for the prevention of blood clots in 1,242 patients from 18 countries undergoing knee replacement surgery who were enrolled between June 2019 and February 2021. They found that at a total daily dose of 100 mg or more, milvexian resulted in bette
New research has revealed that the tau protein, which is important in the development of Alzheimer's disease, is also involved in normal learning processes in the healthy brain, potentially providing a target for future drug therapies.
Glioblastoma is the most lethal and malignant adult brain cancer that may arise from the neuroglial stem or progenitor cells. Certain gene mutations or those with a known history of other cancers and radiation therapy may predispose patients to develop brain cancer. Tumour relapse is invaria
Researchers unravel the genetic complexity of two rare inherited vitamin B12 conditions identifying them as hybrid syndromes that are both a vitamin B12 disorder and a disease of ribosomes, the protein-building machinery of the cell.
New research has revealed how the tau protein, a critical element in the formation of Alzheimer's disease, is also involved in normal learning processes in the healthy brain, potentially providing a focal point for future drug therapies.
Published today in Stem Cell Reports, researchers from the University of Minnesota Medical School discovered two signaling pathways that are downregulated in human hearts after birth. These pathways, mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)-AKT, lead to ma
A new study suggests that therapeutic interventions to treat neurodevelopmental disorders may be more effective if done during the early stages of brain development.
Researchers have identified a subpopulation of mesenchymal stem cells in the bone marrow that express the marker CD73. These cells have a higher potential for proliferation and differentiation, and play a significant role in bone healing, migrating to the site of a fracture and developing in
Being overweight increases the risk of an imbalance in sugar metabolism and even of diabetes. A research group at the University of Basel has now shown the opposite is true as well: deficits in the body's insulin production contribute to being overweight.