The Spaniard reached the third round with a 6-4, 6-7(3), 6-3. 7-6(3) win over Italian playing at the Rod Laver Arena in a match that lasted for three hours and 25 minutes.
The WTA Tour will have a WTA 500 event at the same time, with reigning Australian Open champion and World No.2 Aryna Sabalenka set to play in the tournament.
The 24-time Grand Slam champion Novak Djokovic, who wrapped up an amazing year on Sunday by winning a record-breaking seventh ATP Finals, has no plans to slow down
"Alternate Arthur Fils will replace Stefanos Tsitsipas on Team Europe for Laver Cup Vancouver 2023. Tsitsipas has withdrawn due to injury," Laver Cup announced the news on X, formerly known as Twitter.
The fifth seed overcame an aggressive display from the 21-year-old Nava, who smashed 72 winners to Ruud's 27 but lacked the consistency needed to pull off an upset.