Playing the final test of the South Africa series, England made a mockery of the 130-run target set by South Africa, chasing it down in just 22.3 overs with nine wickets to spare.
Giselle Ansley (3') Tess Howard (40'), Hannah Martin (53') found the back of the net for England and Vandana Katariya (60') was the only scorer for India.
England made history on Sunday when they were crowned UEFA Euro 2022 Champions. It is also the first time since 1966 that England won an international trophy.
Spain frustrated their opposition by dominating in terms of ball possession and shots, but England kept their nerves to snatch the win from jaws of defeat.
Kohli, who missed out on the first ODI due to a groin strain, smashed three boundaries against England in the second ODI before getting out by David Willey.
An unbeaten ton by Roy and an unbeaten knock of 86 runs by Buttler helped England chase the target of 245 runs in just 30.1 overs and at a loss of only two wickets, here at the VRA Cricket Ground, Amstelveen.