The use of antibiotics can be beneficial in treating bacterial infections, but they can also destroy the beneficial microorganisms that are found in the gut, which can have long-term health effects.
Researchers at Brigham and Women's Hospital (BWH) and Massachusetts General Hospital (MGH), two of the founding institutions of Mass General Brigham, have discovered the metabolic mechanisms Clostridioides difficile uses to quickly invade the gut.
Clostridioides difficile, often referred to as C. difficile or C. diff, is a bacterium that causes severe intestinal illness and, as its name suggests, can be difficult to study and treat. Approximately 1 in 6 patients infected with C. difficile will be reinfected within two months. Yet scie