Fighting for series honours may be over, though Dasun Shanaka's side show no interest in slowing down, looking to hand the tourists another blow ahead of the upcoming World Test Championship series.
Indian batters struggled to tackle the Lankan bowling attack properly, with only Shafali Verma, captain Harmanpreet Kaur and Jemimah Rodrigues putting some resistance.
Harmanpreet has been India's T20 captain since 2018, the experienced 33-year-old now takes the reins from Mithali for 50-over cricket ahead of a vital period for India's Women's team.
India were allotted one team and the two leading stars Aditi Ashok and Tvesa Malik were invited, but as per Women's Golf Association of India, they conveyed their regrets. They were replaced by Diksha Dagar and Gaurika Bishnoi.
Du Plessis is among a group of players that are no longer contracted by Cricket South Africa and it remains to be seen whether any free agents will be selected to play for the Proteas at the T20 showcase that starts in Australia in October.
Mumbai will face Madhya Pradesh in the Ranji Trophy 2022 finals. Mumbai, who are 41-time champions have reached their 47th Ranji Trophy final overall and their first since 2016-17.