Stokes has been ruled out of the Multan Test on Monday after he failed to recover from his hamstring injury. In the absence of Stokes, wicketkeeper-batter Ollie Pope will lead the Three Lions against Pakistan in the first Test.
In the run-chase of 310 runs, Australia was given a fine start by openers Travis Head and Matthew Short. The duo plundered runs heavily in the fourth to sixth over.
Following Brook and Liam Livingstone's hard-hitting knocks, the seamers Jofra Archer, Brydon Carse and Matthew Potts took the centre-stage, sharing nine wickets among themselves to guide England to another confidence-boosting victory that levels the five-match series 2-2 and sets up an excit
Lancashire batter Josh Bohannon will captain the squad after leading the County Championship Division One run-scoring last summer with 1,257 runs at an average of 59.85 with four centuries
Gus Atkinson, Harry Brook, Brydon Carse, Sam Curran and Liam Livingstone join the white-ball skipper, with the first two 50-over matches to be played in Antigua.
Seven players Rehan Ahmed, Gus Atkinson, Harry Brook, Brydon Carse, Ben Duckett, Matthew Potts and Josh Tongue receive an England Central Contract offer for the first time.