Sania Mirza was competing in her final Grand Slam with Rohan Bopanna where the duo were defeated 7(7)-6(2), 6-2 by Brazillian Luisa Stefani and Rafael Matos.
The 22nd seed overpowered Jelena Ostapenko 6-2 6-4 in a one-hour and 19-minute encounter, becoming the first woman representing Kazakhstan to reach the final four at Melbourne Park.
The sixth seed rallied from a set down to win on Margaret Court Arena with scores of 3-6, 3-6, 6-3, 6-2, 6-2, keeping him alive in his quest to top his quarterfinal performance from Melbourne last year.
Anwesha Gowda, who is ranked eighth among junior players worldwide, defeated Pitchaya Elysia Viravong Australia, in the BWF Super 300 tournament's opening round in 21 minutes 21-9, 21-11.