The Italian No.8 seed, who had won back-to-back grass titles during his Wimbledon preparations, said he was "heartbroken" to have to miss out. "The dream is over for this year but I will come back stronger."
Centre Court and Court 1 at the All England Lawn Tennis Club are both fitted with a roof, meaning their schedules will commence as planned regardless of the weather.
The reigning Indian Wells champion Taylor Fritz added his second title of the season to his list of accolades after defeating Maxime Cressy 6-2, 6(4)-7, 7-6(4) in an all-American battle.
With this win Andy Murray upped his preparation for Wimbledon 2022, beginning later in June, by wonderfully using his backhand slices to control the sets and outplayed Tsitsipas by 7-6 (4), 6-3.