Tiafoe, who defeated Wu Yibing on Wednesday to start his campaign, maintained his excellent play to reach the third round for the fifth consecutive major tournament. The American won the final two sets after fending off four set points in a lengthy opening tie-break.
The Russian will keep his World Number 1 ranking on the line against Kyrgios, who had defeated Medvedev at ATP Masters 1000 event in Canada to extend his head-to-head lead against him to 3-1. If he falls to Kyrgios, he will lose his World Number one crown.