A novel gene has been linked by researchers in Berlin and Dusseldorf to the development of Huntington's disease in a brain organoid model. Earlier than previously believed, the gene may play a role in brain disorders.
Huntington's disease is the most prevalent neurodegenerative ailment caused by a single gene, with motor and cognitive abnormalities as well as behavioural symptoms. There are no medicines that can stop or reverse the condition at the moment, but new research from Boston Children's Hospital
"DNA breaks and repair events occur thousands of times per day in each of us," said Freudenreich. "Most of the time, repair works the way it should. But we now have a better understanding of how things can go wrong, and we can apply this knowledge to new therapeutic strategies."
UC Davis researchers are the first to describe how oligodendrocyte-lineage cells transfer cell material to neurons in the mouse brain. Their findings show that these cells and neurons interact in a coordinated nuclear manner.
Neurons in the striatum, a part of the brain affected by Huntington's disease, are among the most severely affected. The degeneration of these neurons contributes to patients' loss of motor control, which is one of the disease's major symptoms.