Study sheds more light on advances, challenges in gene therapy for rare diseases

Immunotherapy research primarily focuses on better recognition of cancer cells by the body's own immune system. Researchers at Amsterdam UMC and Moffitt Cancer Center have taken a different approach.

Marking Rare Disease Day, Strand Life Sciences, a subsidiary of Reliance Industries and a leading genomics research company, has launched the StrandOmics Portal, an innovative digital platform designed to assist doctors in diagnosing rare diseases more efficiently.

A COVID-19 diagnosis is no longer as frightening as it used to be, thanks to developments in treatment choices. However, a new study reveals that leukocyte (white blood cell) count may now be used to identify who is more likely to develop more significant disease symptoms.

The matter of what causes complicated neurological disorders like Alzheimer's or multiple sclerosis continues to perplex scientists and doctors, with unknowns impeding early diagnosis and successful treatment.

Columbia researchers developed probiotic bacteria that train the immune system to eliminate cancer cells, paving the way for a new class of cancer vaccinations that take advantage of bacteria's innate tumour-targeting abilities. These microbial cancer vaccines can be tailored to each person's specific original tumour and metastases, perhaps preventing future recurrences.

Researchers at Colorado State University discovered an alternative way for studying alterations during the DNA replication process in lab settings using genetically modified yeast. The novel methodology provides a clearer picture than current pharmacological methods for understanding cell cycle arrest, a fundamental mechanism critical to cancer treatment and genetic concerns.

Alzheimer's disease may cause brain damage in two stages, according to new research supported by the National Institutes of Health (NIH) that uses sophisticated brain mapping methods.

Pancreatic cells, like human cells, have a limit to how much stress they can handle before they start to break down. Through overstimulation of these cells, certain stresses like inflammation and hyperglycemia lead to the onset of type 2 diabetes.

The majority of cancer deaths are caused by metastatic disease, which occurs when cancer spreads from the primary tumour to other areas of the body. and researchers understand how cancer cells escape the primary location to seed new tumours, it is unclear why some cancer cells produce new tumours decades later and others do not.

The significance of gamma-delta T cells in 33 different cancer types is revealed in a recent study that was published in Cell Press. This information sheds light on the cells' potential as clinical biomarkers and therapeutic targets in the treatment of cancer. This thorough examination, which was carried out under the direction of a group of Moffitt Cancer Center experts, marks a substantial breakthrough in our knowledge of these distinct immune cells and how they affect cancer therapy outcomes for patients.