ADD ANI AS A TRUSTED SOURCE
googleads
ANI Logo
Menu
Health

Study suggests how cancer spreads to the brain

Options for treatment are limited when cancer spreads to the brain. The majority of medications made to fight metastases either cannot penetrate the blood-brain barrier or are ineffective against brain metastases.

ANI Apr 03, 2023 15:56 IST googleads

Representative Image

Ann Arbor [Michigan], April 3 (ANI): Options for treatment are limited when cancer spreads to the brain. The majority of medications made to fight metastases either cannot penetrate the blood-brain barrier or are ineffective against brain metastases.
"Understanding how cancer cells thrive or fail in the brain niche could help us develop new treatments targeting these molecular processes," said Sofia Merajver, M.D., Ph.D., the Greater Good Breast Cancer Research Professor at the University of Michigan Rogel Cancer Center.
Merajver and colleagues used two microfluidic chips to record cancer cell migration to the brain and examine what was occurring in the blood-brain niche in order to comprehend the molecular mechanisms that affect how cancer cells pass through the blood-brain barrier. The journal Advanced NanoBiomed Research publishes the findings.
Using breast cancer cell lines, they found that Dkk-1, a cytokine released by the astrocytes, triggers the cancer cells to migrate. Dkk-1 is known to play a role in in Wnt signaling, a key signaling pathway linked to cancer progression.
"Crosstalk between brain niche cells and cancer cells allows invading cancer cells to permeate the blood-brain barrier. Reducing Dkk-1 levels near invading tumor cells might disrupt this crosstalk and prevent brain metastases," said corresponding author Christopher R. Oliver, Ph.D., a post-doctoral fellow in the Merajver Lab. (ANI)

Get the App

What to Read Next

Health

The truth about ‘Eating for Two’ explained by doctors

The truth about ‘Eating for Two’ explained by doctors

Health experts warn that interpreting the advice literally can lead to excessive calorie intake, unhealthy weight gain and a higher risk of Gestational Diabetes Mellitus (GDM), a condition that affects blood sugar levels during pregnancy.

Read More
Health

High-fat keto diet may boost exercise benefits

High-fat keto diet may boost exercise benefits

A new study suggests that eating more fat rather than less could help the body gain greater benefits from exercise when blood sugar levels are high, offering an unexpected perspective on how diet and physical activity work together to support metabolic health.

Read More
Health

The more you fear aging, the faster your body may age

The more you fear aging, the faster your body may age

Worrying about getting older especially fearing future health problems may actually speed up aging at the cellular level, according to new research from NYU.

Read More
Health

Scientists discover reason high altitude protects against diabete

Scientists discover reason high altitude protects against diabete

Living at high altitude appears to protect against diabetes, and scientists have finally discovered the reason. When oxygen levels drop, red blood cells switch into a new metabolic mode and absorb large amounts of glucose from the blood.

Read More
Health

Scientists reveal how exercise protects brain from Alzheimer's

Scientists reveal how exercise protects brain from Alzheimer's

Exercise may sharpen the mind by repairing the brain's protective shield. Researchers found that physical activity prompts the liver to release an enzyme that removes a harmful protein, causing the blood-brain barrier to become leaky with age.

Read More
Health

Scientists find clue to human brain evolution in finger length

Scientists find clue to human brain evolution in finger length

Human evolution has long been tied to growing brain size, and new research suggests prenatal hormones may have played a surprising role. By studying the relative lengths of the index and ring fingers, a marker of prenatal exposure to oestrogen and testosterone, researchers found that higher prenatal oestrogen exposure was associated with larger head size in newborn boys.

Read More
Health

MRI scans show exercise can make the brain look younger

MRI scans show exercise can make the brain look younger

New research suggests that consistent aerobic exercise can help keep your brain biologically younger. Adults who exercised regularly for a year showed brains that appeared nearly a year younger than those who didn't change their habits.

Read More
Health

Scientists solve a major roadblock in cancer cell therapy: Study 

Scientists solve a major roadblock in cancer cell therapy: Study 

Researchers have found a reliable way to grow helper T cells from stem cells, solving a major challenge in immune-based cancer therapy. Helper T cells act as the immune system's coordinators, helping other immune cells fight longer and harder.

Read More
Health

Scientists find hidden synapse hotspots in the teen brain: Study

Scientists find hidden synapse hotspots in the teen brain: Study

The scientists have discovered that the adolescent brain does more than prune old connections. During the teen years, it actively builds dense new clusters of synapses in specific parts of neurons.

Read More
Health

Memory loss can suddenly speed up with age: Study

Memory loss can suddenly speed up with age: Study

A massive international brain study has revealed that memory decline with age isn't driven by a single brain region or gene, but by widespread structural changes across the brain that build up over time.

Read More
Home About Us Our Products Advertise Contact Us Terms & Condition Privacy Policy

Copyright © aninews.in | All Rights Reserved.