P2X4 receptor helps in curing multiple sclerosis

In a study published November 5 in Nature, the team found that microglia with lower levels of a transcription factor called PU.1 and higher expression of a receptor known as CD28 help reduce brain inflammation.

About 100,000 of the estimated million persons in the United States with multiple sclerosis (MS) have a progressive form of the disease, with symptoms worsening over time or following periods of remission.

A group of astronomers from across the globe, including a team from the University of Washington and led by Queen's University Belfast, have revealed new research showing that millions of new solar system objects will be detected by a brand-new facility, which is expected to come online later this year.

In a startling discovery, a team of Boston University researchers found that bacteria exposed to microplastics became resistant to multiple types of antibiotics commonly used to treat infections.

A biohybrid hand which can move objects and make a scissor gesture has been created. The researchers used thin strings of lab-grown muscle tissue bundled into sushilike rolls to give the fingers enough strength to contract. It is named multiple muscle tissue actuators (MuMuTAs).

Researchers have conducted one of the largest eye studies in the world to reveal new insights into retinal thickness, highlighting its potential in the early detection of diseases like type 2 diabetes, dementia and multiple sclerosis.

Researchers at the University of Colorado Anschutz Medical Campus found a promising therapeutic candidate that could aid in the restoration of vision in those suffering from multiple sclerosis (MS) and other neurodegenerative diseases.

The study, led by Patrizia Casaccia, founding director of the Advanced Science Research Centre at the CUNY Graduate Center's (CUNY ASRC) Neuroscience Initiative and Einstein Professor of Biology and Biochemistry at the CUNY Graduate Centre, investigated how enzymes known as ceramide synthase 5 and 6 are responsible for the toxic effect of a palm oil-rich diet on neurones in the central nervous system, which leads to an increase in the severity of MS symptoms.

Researchers have made great strides in understanding how cells interact during inflammation. The study, just published in PNAS, was undertaken over a five-year period and focused on the chemicals that allow cells to function during inflammation, particularly in the central nervous system, where disorders such as multiple sclerosis develop.

The protein receptor Tyrosine phosphatases are proteins that are found in cell membranes. Although the details of their exact mechanism of action remain unknown, they are known to be tumour suppressors and regulators of cell-cell interactions.