Inner membrane of Mitochondria changes structure every few seconds, finds study

Washington D.C. [USA], Feb 22 (ANI): A group of researchers has discovered that the inner membrane of mitochondria - the powerhouse of all living cells - is constantly moving rather than being static as it continuously changes its structure every few seconds. This dynamic adaptation process further increases the performance of our cellular power plants.
However, up till recently, it was assumed that these vital functions are carried out within a static and unmoving structure of mitochondrial membranes, but the new finding by the researchers from Heinrich Heine University Dusseldorf (HHU) and the University of California Los Angeles (UCLA) seems to challenge this theory.
"In our opinion, this finding fundamentally changes the way our cellular power plants work and will probably change the textbooks," says Prof. Dr Andreas Reichert, Institute of Biochemistry and Molecular Biology I at the HHU. The results are described in a publication in EMBO Reports.
Researchers at the Heinrich Heine University Dusseldorf (HHU) and the University of California Los Angeles (UCLA), supported also by the Center for Advanced Imaging (CAi) of HHU,
Mitochondria are extremely important components in cells performing vital functions including the regulated conversion of energy from food into chemical energy in the form of ATP. ATP is the energy currency of cells and an adult human being produces (and consumes) approximately 75 kilograms of ATP per day.
One molecule of ATP is produced about 20,000 times a day and then consumed again for energy utilization. This immense synthesis capacity takes place in the inner membrane of the mitochondria, which has numerous folds called cristae.
It was previously assumed that a specific static structure of the cristae ensured the synthesis of ATP. Whether and to what extent cristae membranes are able to dynamically adapt or alter their structure in living cells and which proteins are required to do so, was unknown.
The research team of Prof. Dr Andreas Reichert with Dr Arun Kondadi and Dr Ruchika Anand from the Institute of Biochemistry and Molecular Biology I of the HHU in collaboration with the research team of Prof. Dr Orian Shirihai and Prof. Dr Marc Liesa from UCLA (USA) succeeded for the first time in showing that cristae membranes in living cells continuously change their structure dynamically within seconds within mitochondria.
This showed that the cristae membrane dynamics requires a recently identified protein complex, the MICOS complex. Malfunctions of the MICOS complex can lead to various serious diseases, such as Parkinson's disease and a form of mitochondrial encephalopathy with liver damage. After the identification of the first protein component of this complex (Fcj1/Mic60) about ten years ago by Prof. Andreas Reichert and his research group, this is another important step to elucidate the function of the MICOS complex.
"Our now published observations lead to the model that cristae, after membrane fission, can exist for a short time as isolated vesicles within mitochondria and then re-fuse with the inner membrane. This enables an optimal and extremely rapid adaptation to the energetic requirements in a cell," said Prof Andreas Reichert. (ANI)